Alterations in the articular cartilage of the femoral head in osteoarthritis by Sally Roberts

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Published by University of Birmingham in Birmingham .

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Thesis (Ph.D.) - University of Birmingham, Dept of Pathology.

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StatementSally Roberts.
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Open LibraryOL13825218M

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Swelling of the cartilage could be early sign of the cartilage alterations because it was initially resulted from proteoglycan degradation activities of the chondrocytes and altered hydration of the cartilage 27 x 27 Lohmnader, L.S., Ionescu, M., Jugessur, H., and Poole, A.R.

Changes in joint cartilage aggrecan metabolism after knee injury and in by: Explore the relationship between the macroscopic aspect of the articular surface and the rate of microscopic changes of both the cartilage and the subchondral bone in OP and osteoarthritis (OA).

Microstructural alterations of femoral head articular cartilage and subchondral bone in osteoarthritis and osteoporosis - Osteoarthritis and CartilageCited by: Early osteoarthritis Articular cartilage Subchondral bone Femoral head summary Objective: To test the hypothesis that changes in the subchondral bone induced by parathyroid hormone (PTH []) reciprocally affect the integrity of the articular cartilage within a naïve osteochondral unit in vivo.

Microstructural alterations of femoral head articular cartilage. and subchondral bone in osteoarthritis and osteoporosis. Bobinacy*, M. Marinovicz, E. Bazduljy, O. Cvijanovicy, T. Celicy, I. Maricy, J. Spanjolx, T. Cicvaricz. yDepartment of Anatomy, School of Medicine.

Microstructural alterations of femoral head articular cartilage and subchondral bone in osteoarthritis and osteoporosis Article in Osteoarthritis and Cartilage 21(11) July with Reads.

Osteoarthritis and Cartilage. Vol Is NovemberPages Microstructural alterations of femoral head articular cartilage and subchondral bone in osteoarthritis and osteoporosis. Author links open overlay panel D. Bobinac Cited by:   Specimens obtained from human osteoarthritic knee joints and dog knees with experimentally induced osteoarthritis were used to study the collagenous framework of articular cartilage and subchondral bone in relation to osteoarthritic changes using scanning electron microscopy and light microscopy.

Degenerative articular cartilage in osteoarthritic joints showed radial Cited by: Articular Cartilage Calcification in Osteoarthritis Insights Into Crystal-Induced Stress Hang-Korng Ea, 1Christelle Nguyen, Dominique Bazin,2 Arnaud Bianchi,3 Je´roˆme Guicheux,4 Pascal Reboul,3 Michel Daudon,5 and Fre´de´ric Liote´1 Introduction Osteoarthritis (OA) is the most common form of rheumatic disease, leading ultimately to Cited by:   The reaction patterns of chondrocytes in osteoarthritis can be summarized in five categories: (1) proliferation and cell death (apoptosis); changes in (2) synthetic activity and (3) degradation; (4) phenotypic modulation of the articular chondrocytes; and (5) formation of osteophytes.

In osteoarthritis, the primary responses are reinitiation of synthesis of cartilage macromolecules, the Cited by: The third edition of this acclaimed book comprehensively synthesizes expert knowledge and clinical aspects of osteoarthritis. Many renowned contributors review current information on epidemiology and pathology of osteoarthritis, including the topics of cartilage repair and biomechanical considerations.

Emphasizes orthopedic procedures, while providing guidelines for the diagnosis and treatment. Avascular necrosis of the femoral head: Overlying thinning and loss of articular cartilage. The role of arthroscopy in the management of AVN is controversial.8,9 There are several reports of femoral head collapse shortly after hip arthroscopy, including several in our series.2,8 It is unclear if it is the natural history of the condition, the.

Shen, Z., Heinegård, D. & Sommarin, Y. Distribution and expression of cartilage oligomeric matrix protein and bone sialoprotein show marked changes during rat femoral head development.

Matrix Cited by: Fig. Macroscopic and histological aspect of the articular cartilage in the weightbearing area of lapine femoral heads. According to the scoring system of Wachsmuth et al. 19, systemic administration of PTH [] did not affect the macroscopic aspect of the femoral heads (A).However, the histological scoring system of Laverty et al.

21 revealed that the treatment significantly increased the Cited by: The acetabulum, which is formed by the large pelvic bone, forms the “socket.” The femoral head forms the “ball.” Further, the surface of the hip joint is covered by synovial fluid.

This serves to lubricate the joint and helps with movement. If you’re suffering from osteoarthritis, the cartilage in your hip joint had begun to wear away. "Hip Preservation" is a surgical intervention that alters the position of the acetabulum to increase coverage of the femoral head and return radiographic measurements to within a normal range.

The goals of hip preservation are to correct the primary deformity, eliminate instability, prevent articular damage, and delay or prevent the onset of OA. To test if the expression of main proteases of the articular cartilage is affected by the altered HS structure, we analyzed the expression of Mmp2, Mmp3, Mmp9, Mmp13, Adamts4 and Adamts5 1, 32, 33 in Ndst1 +/− femoral head cultures treated with RA to induce cartilage degradation 34 by qRT-PCR.

Written by the foremost experts, this text is a comprehensive clinical reference on osteoarthritis. Chapters review current information on the epidemiology, etiopathogenesis, and pathology of osteoarthritis, the biochemistry and molecular and cell biology of articular cartilage, and experimental models of osteoarthritis.

Major sections focus on clinical presentations, roentgenologic and 2/5(1). CONCLUSIONS: The aberrant nonspherical portion of the femoral head in young patients with an impingement conflict consists of hyaline cartilage which shows clear degenerative signs similar to the findings in osteoarthritic cartilage.

The tissue alterations are distinctly different when compared with a control group, which substantiates an impingement conflict as an early mechanism for degeneration Cited by: However, it does allow for ° inspection and treatment of the acetabulum and femoral head.

To address the femoral head, an excision osteoplasty is normally done. There is often a clear demarcation between normal femoral articular cartilage and the area of the head subjected to FAI. The hyaline cartilage may show fraying and furrowing and. Osteoarthritis was diagnosed in (I'm 47 and vey active) New MRI results: ior defect in root of medial meniscus 2.

interstitial tear in ACL 3. bone marrow abnormality at medial femoral condyle 4. mild cartilage deficit lateral femoral condyle All my pain is posterior lateral with limited flexion. In cases with significant bone alterations, cartilage and bone degradation continue with joint pain. We propose that this is the end-staged OA.

Since the number of cases were relatively small in this study as well as our previous study [ 6 ], it is currently speculative the Cited by: 9. Hip arthritis commonly describes the most common for of hip arthritis, which is known medically as hip osteoarthritis.

Hip osteoarthritis is a joint disease that mostly affects your hip joint cartilage. Articular cartilage is the hard slippery surface that covers the sections of.

Also, femoral heads from week-old mice showed a increase in LUM (not shown). The femoral heads contain bone tissue in addition to articular cartilage and the observed quantities of LUM may reflect an increase in bone.

However, processus xiphoideus extracts, containing cartilage only, demonstrated at both 12 and 20 weeks a. Coronal fat-suppressed image from a MR arthrogram demonstrates loss of femoral head and acetabulum articular cartilage (arrows). A small osteophyte is seen on the superolateral femoral head.

Figure (A) Anteroposterior radiograph of the left hip demonstrates a loose body (arrow), as well as early degenerative change of the femoral head. Bobinac D, Marinovic M, Bazdulj E et al. Microstructural alterations of femoral head articular cartilage and subchondral bone in osteoarthritis and osteoporosis.

Osteoarthritis Cartilage Cited by: Figure 3. “Tilt deformity” in osteoarthritis. A radiograph of the coronal section of the femoral head (illustrated in Figure 2) reveals the original zone of calcified cartilage (open arrowheads), the medial femoral osteophyte (open arrows), and buttressing or cortical thickening of the medial portion of the femoral neck (curved arrow).Cited by: Osteoarthritis is the most common type of joint disease, affecting more than 30 million individuals in the United States alone.

[] It is the leading cause of chronic disability in older adults, costing the US greater than $ billion annually. [] It can be thought of as primarily a degenerative disorder with inflammatory components arising from the biochemical breakdown of articular (hyaline.

Jones IL, Klämfeldt A, Sandström T. The effect of continuous mechanical pressure upon the turnover of articular cartilage proteoglycans in vitro. Clin Orthop Relat Res.

May;()– Ladefoged C. Amyloid in osteoarthritic hip joints. A pathoanatomical and histological investigation of femoral head by:   Microstructural alterations of femoral head articular cartilage and subchondral bone in osteoarthritis and osteoporosis Dragica Bobinac 1, Tanja Celic 1, Marin Marinovic 2 & Ivana Maric 1.

Author affiliations. Decreased acetabular coverage of the femoral head gave altered mechanical load, with ensuing cartilage degeneration. For comparison, degenerative knee joint disease was induced in other dogs by transection of the anterior cruciate ligament of the knee.

The femoral head articular cartilage showed macroscopic signs of degeneration within a by: The aberrant nonspherical portion of the femoral head in young patients with an impingement conflict consists of hyaline cartilage which shows clear degenerative signs similar to the findings in. The estimated overall prevalence of radiographic hip osteoarthritis in persons 45 years or older is %, of which % of individuals are estimated to be symptomatic.

15 Generally, women are affected more so than men. 1,15 The reported prevalence of hip osteoarthritis in the literature varies greatly depending on the characteristics of the cohort and the definition of osteoarthritis applied.

thelateral aspect ofthe femoral head. Histologic evaluation of femoral heads demonstrating this tYpe ofmigratory pat-tern outlined articular cartilage loss along the outer one-third ofthe femoral surface with relative preservation of cartilage along the inner and medial aspects ofthe femoral head.

Thickening ofstress trabecu. Introduction. This is a series of clinical case reports demonstrating that a combination of percutaneously injected autologous adipose-tissue-derived stem cells, hyaluronic acid, platelet rich plasma and calcium chloride may be able to regenerate bones in human osteonecrosis, and with addition of a very low dose of dexamethasone, cartilage in human knee by: an early event in this model of osteoarthritis.

Early osteoarthritis is characterized by articular cartilage matrix alterations and increased chondrocyte metabolism. The interrelationship of these events with Presented in part at the 51st Annual Meeting of the Amer- ican Rheumatism Association, Washington, DC. Osteoarthritis.

Osteoarthritis (OA) is a disorder of diarthrodial joints that is characterized clinically by pain and functional limitations, radiographically by osteophytes and joint space narrowing, and histopathologically by alterations in cartilage and subchondral bone integrity.

From: Goldman's Cecil Medicine (Twenty Fourth Edition), Alterations of High-Mannose Type N-Glycosylation in Human and Mouse Osteoarthritis Cartilage Atsushi Urita, 1Tomoya Matsuhashi, Tomohiro Onodera, Hiroaki Nakagawa,2 Megumi Hato,2 Maho Amano,2 Naoki Seito, 1Akio Minami, Shin-Ichiro Nishimura,2 and Norimasa Iwasaki Objective.

The process of N-glycosylation is in-volved in the pathogenesis of Cited by: Total hip arthroplasty is an elective procedure, performed for the treatment of debilitating pain. Osteoarthritis is the etiology for 60% of THA (contribution of unrecognized dysplasia is controversial), femoral neck fractures and other trauma 10%, rheumatologic causes about 10%, AVN about 10%, is about 10% other causes.

osteoarthritis and satisfactory outcomes with hip arthroscopy can be expected. (1e and 1f) More advanced stages of osteoarthritis lead to thinning and ulceration of the cartilage in the acetabulum load-bearing surface (1e, white arrow), progression of degenerative cartilage damage of the femoral head (1e black arrow), and formation of Cited by:   In end-stage osteoarthritis (OA) of the hip, the effect of bone metabolism with and without cartilage is unclear.

In this study, we aimed to investigate histomorphology and microdamage in the subchondral bone of the femoral head in areas with and without articular cartilage in patients with end-stage OA. Nineteen femoral heads were evaluated in 10 women who underwent total hip Author: Masashi Shimamura, Ken Iwata, Tasuku Mashiba, Takanori Miki, Tetsuji Yamamoto.

Articular cartilage damage most commonly occurs in the knee, but the elbow, wrist, ankle, shoulder, and hip joint can also be affected.

In severe cases, a piece of cartilage .Results: Cartilage thickness at the medial femoral condyle (P femoral cartilage cross-sectional area (P = ) were smaller in the injured compared to the uninjured limb.Start studying Chapter 37 & Alterations of Musculoskeletal Function.

Learn vocabulary, terms, and more with flashcards, games, and other study tools. local areas of damage and loss of articular cartilage, new bone formation of joint margins, subchondral bone changes, variable degrees of mild synovitis and thickening of joint capsule.

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